European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND OPTIMIZATION OF SUSTAIN RELEASE INDOMETHACIN CAPSULE

*Preeti Khulbe and Birendra Srivastava

ABSTRACT

Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) which is commonly used as prescription drug to reduce fever, stiffness and pain. In this Indomethacin is used as model drugs. Different formulations were prepared by using optimization technique. Wet granulation method was used for making Indomethacin sustain release granules. In this method rate retarding polymers (Guar gum, Xanthan gum & ethyl cellulose) were added in the formula. Ex vivo permeation study was performed in selected optimized batch. Non-everted intestinal sac method was used to determine Ex-vivo permeation study. After optimization statistical analysis of optimized formulations were performed on the bases of full factorial 23 design by using response surface plot, ANOVA and order of reaction. Prepared optimized formulation was compared with marketed formulation. The prepared optimized capsule is having 99.84% drug release from sustained release indomethacin upto 12 hrs.

Keywords: Indomethacin, sustained release, Ex vivo, Xanthan gum, Guar gum.