European Journal of Biomedical and Pharmaceutical Sciences

GC-MS ANALYSIS AND ANTIMICROBIAL POTENTIAL OF GARCINIA XANTHOCHYMUS, Hook. F. ex J. Anders., LEAF EXTRACT

Kandasamy Palanisamy Jaiganesh*, Nataraj Priya, Ramamoorthi Karthik and Balakrishnan Sreedharren

ABSTRACT

Garcinia xanthochymus, is a medium-sized, glabrous, deciduous tree, is one of the medicinally important plant belonging to the Family Clusiaceae. Traditionally fruits of the plant are used as anthelmintic, cardio tonic and improve appetite. Ripe fruit is tonic, invigorating and alexipharmic, good in heart trouble and biliousness. In the present investigation, preliminary phytochemical screening, GC-MS analysis and antimicrobial studies were carried out for ethanol extracts (leaf and stem) against gram positive bacteria (Staphylococcus aureus), gram negative bacteria (Escherichia coli) and fungi (Aspergillus niger) by detecting the zone of inhibition using agar well diffusion method. Preliminary phytochemical screening showed the presence of phenolic compounds and flavonoids. GC-MS analysis of ethanolic of leaf and stem extracts of Garcinia xanthochymus were exhibited the presence of 24 and 17 compounds respectively as reported 2,3-dihydro benzofuran, nepetalactol, neophytodiene and squalene. Ethanol of leaf and stem extracts (25, 50, 100 mg/ml) exhibited significant antimicrobial activity against bacteria and fungi using the respective standard antibiotics (10μg/ml).

Keywords: Garcinia xanthochymus, Phytochemical study, GC-MS analysis, Antimicrobial activity.