European Journal of Biomedical and Pharmaceutical Sciences

INVESTIGATION OF ANTIHYPERTENSIVE ACTIVITY OF YOUNG SHOOTS AQUEOUS EXTRACT OF AEGLE MARMELOS (L.) IN DOCA SALT INDUCED HYPERTENSIVE RATS

Kanakam Vijayabhaskar*, Hemanth Kyatham, Mohammed Jaffer Sadik, Nimma Vijaya Rekha, Polu Pavan Kumar and Kurimilla Swathi

ABSTRACT

The present study was designed to determine the antihypertensive activity of young shoots Aq-extract of Aegle marmelos linn using DOCA salt induced antihypertensive model. The plant material was extracted by cold extraction method using solvent water. A. marmelos is belonging to Rutaceae family), has a great potential against various disorders. For evaluation of this activity male albino wistar rats were uninephrectomized and randomly divided into five groups. Hypertension was induced by injecting DOCA-salt, 25 mg/kg BW subcutaneously, twice a week for six weeks, with NaCl 1% instead of tap water for drinking throughout the study. Systolic and diastolic Blood pressure was measured every week. Aegle marmelos showed significant anti hypertensive effect in DOCA salt induced hypertensive rats in dose of 100mg/b.w and 200mg/b.w.

Keywords: Aegle marmelos, Antihypertensive effects, Uninephroctomy, DOCA salt.