Abstract
VALIDATED HPLC METHOD FOR ESTIMATION OF ROSIGLITAZONE IN BULK AND TABLET DOSAGE FORM

Kollu Sravyasri*, Dr. M. Dhanalakshmi and Asra Farheen

ABSTRACT

A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Rosiglitazone, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Symmetry C18 (4.6 x 150mm, 5μm) column using a mixture of Acetonitrile: Water (50:50v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 245nm. The retention time of the Rosiglitazone was 2.4 ±0.02min respectively. The method produce linear responses in the concentration range of 15-75mg/ml of Rosiglitazone. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.

Keywords: Rosiglitazone, RP-HPLC, validation.


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