Abstract
ANTIDANDRUFF ACTIVITY AND CHEMICAL CONSTITUENTS OF THE ROOTS OF SAUSSUREA COSTUS (FALC.) LIPSCH

Chhavi Singla* and M. Ali

ABSTRACT

Saussurea costus (Falc.) Lipsch. (Asteraceae) grows in the Himalayan region and its roots are used to treat abdominal, blood, kidney and liver disorders, respiratory and skin diseases, cholera, convulsion, general debility, erysipelas, fever, headache, helminthiasis, malaria, irregular menses, paralysis, rheumatism and ulcers. The air-dried root powder was extracted exhaustively with methanol in a Soxhlet apparatus. The concentrated methanolic extract was dissolved in 95% aqueous methanol and fractionated by partitioning the solution with petroleum ether, chloroform, ethyl acetate and n-butanol. The chloroform fraction exhibited marked antidandruff activity against the growth of human skin fungus Malassezia furfur. It was adsorbed on silica gel (60-120 mesh) for the preparation of a slurry. The dried slurry was loaded over silica gel columns. The column was eluted with petroleum ether, chloroform and methanol, successively, in order of increasing polarity to isolate nonadecan-1-ol (1), stearic acid (2), henetriacontan-1-ol (3), pentatriacontan-1-ol (4), n- pentatriaconta-1,19β-diol (5), n-nonadecanyl stearate (6) and hexatetracontan-1-ol (7). Their structures were established on the basis of spectral data analysis and chemical reactions.

Keywords: Saussurea costus, roots, antidandruff activity, phytoconstituents, isolation, characterization.


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