European Journal of Biomedical and Pharmaceutical Sciences

REVIEW ON NANOSPONGE: A NOVEL DRUG DELIVERY SYSTEM

Bhalekar Rohini V., Nagoba Shivappa N.*, Shaikh Nasheer S. and Chandrawanshi Mayuri J.

ABSTRACT

Nanosponges are a novel class of hyper-crosslinked polymer based on colloidal structures consisting of solid nanoparticles with colloidal sizes and nanosized cavities. These are nano-sized colloidal carriers have been recently developed and proposed for drug delivery, since their use can solubilize poorly water-soluble drugs and provide prolonged release as well as improve a drugs bioavailability by modifying the pharmacokinetic parameters of actives. Nanotechnology attacked increasing attention during recent year it can resolve the problem associated with solubility and bioavailability. The development of new and complex molecules Nanosponges has potential to solve these problems. Nanosponges is tiny sponges size of about the virus which is filled with drug and complex molecule. It can circulate around the body until they encounter the specific targeted site and stick on the surface and being release the drug in controlled manner. Because the drug can be released at the specific targeted site instead of circulating throughout the body it will be more effective for particular given dosage. This review is focusing on the preparation method, application of Nanosponges in the field of drug delivery.

Keywords: Nanotechnology, Nanosponges, poorly solubility of drug, controlled manner.