COMPARATIVE HISTOPATHOLOGICAL EFFECTS OF METFORMIN AND GLIBENCLAMIDE ON PANCREAS IN ALLOXAN INDUCED DIABETIC ALBINO RATS
Nuzhat Bashir, Aijaz Ahmad Patloo* and Nadia Bashir
ABSTRACT
Introduction: Diabetes mellitus is a systemic metabolic disorder characterised by elevated blood glucose levels due to absolute or relative deficiency of insulin secretion from pancreatic β-cells. It is implicated in oxidative stress which induces insulin resistance in the peripheral tissue and impairs insulin secretion from pancreatic beta cells. In this study we evaluated the comparative histopathological effect of Metformin and Glibenclamide on Pancreas in Alloxan induced diabetic rats. Material and Methods: The present study was conducted on 24 experimental animals which were divided into four groups of with 6 rats in each group and were treated accordingly Group 1:Healthy control (HC) rats, Group 2: Diabetic control (DC) rats,Group 3: Diabetes mellitus (DM) + Metformin(M) rats,Group 4: Diabetes mellitus (DM) + Glibenclamide(G) rats.After 28 days of treatment rats were sacrificed and blood glucose and body weight was determined along with histopathological study of pancreas. Result: The results showed that both Metformin and glibenclamide reversed Alloxan induced diabetic histopathological changes in Pancreas in Albino rats. Conclusion: The present results demonstrate that normoglycemia with metformin and glibenclamide ameliorates diabetic induced histopathological lesions in Pancreas.
Keywords: Diabetes, histopathology, Pancreas, Metformin, Glibenclamide.
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