Srinivas Vandavasi* and Grandhi Surendra


Hyperlipidemic is the one of the risk factor responsible for atherosclerosis, and cardiovascular diseases.The aim of present work is to screen the antihyperlipidemic activity of Macrotyloma uniflorum Linn leaves extract in cholesterol diet induced hyperlipidemic rats. Wister albino rats were divided into 5 groups and were treated with (control) normal rats without cholesterol diet, (toxic control) cholesterol diet only, (standard)cholesterol diet + Atrovastatin (10mg/kg) b.w , (Test group-1) pet ether extract treated group+ cholesterol diet (Test group-2) chloroform extract +cholesterol diet, (Test group-3) ethanol extract + cholesterol diet . Respectively for 20 days. Data expressed as mean ± S.E.M and analyzed statistically using ANOVA followed by Dunnet’s ‘T’ test and compare with respective control group. Chloroform extract treated group at a dose of 100mg/kg b.w has reduced significantly Total cholesterol, Triglycerides, Low density lipoprotein , Very low density lipoprotein and consecutively increased the level of High density lipoproteins . Ethanolic extract group has shown moderate significant action, whereas petroleum ether extract group has shown very low significant action. It can be conclude that the constituents like alkaloids, flavonoids which are present in chloroform extract of Macrotyloma uniflorum may be responsible for the activity.

Keywords: High density cholesterol level, Low density cholesterol level, Very low density cholesterol level, Macrotyloma uniflorum Linn.

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