Abstract
DESIGN AND IN-VITRO EVALUATION STUDIES OF TELMISARTAN LIPOSOMAL FORMULATIONS

B. Premkumar* and A. Srinivasa Rao

ABSTRACT

The aim of the present study was to develop a liposomal gel formulation for antihypertensive drug telmisatran. Liposomal carriers are well known for their topical drug delivery system with an advantage to overcome serious gastrointestinal complications for steroidal or non steroidal drugs given in oral route. Liposomes with various concentrations of cholesterol were prepared using thin film hydration technique (vacuum rotatory evaporator). The liposomal formulation was incorporated in gel (carbopol) and characterized. The SEM analysis showed surface morphology of liposomal formulation was achieved. The FTIR analysis showed there is no specific interaction between drug and excipients. The in-vitro studies revealed that liposomal gel formulation exhibits increased permeation showing sustain. The future studies are warranted to develop commercial liposomal gel formulation for the treatment of hypertension.

Keywords: Liposomes, Telmisatran, FTIR & in-vitro studies.


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