ANTIOXIDANT AND ANTICANCER ACTIVITY OF MOMORDICA CHARANTIA
Jyoti Singh and Prof. R. K. Singh*
ABSTRACT
Since ancient times, a variety of plants have been used as medicine and vegetable throughout the world. The combination of medicine and vegetable usage have Momordica charantia popular for thousand years. Momordica charantia (Figure 1), a valuable plant, belongs to the cucurbitaceae family; it is commonly known as bitter gourd, bitter melon, kugua or karela. Natural products are the best source for various medicinal drugs. The enzymatic and non-enzymatic antioxidative capacities of bitter gourd (Momordica charantia) were investigated in water extract .this study aimed to identify antioxidant and anticancer activity of Momordica charantia extract on different cell lines like HEPG2, HCT116 and MCF-7. Total phenolic compounds free radical DPPH scavenging activity and SOD activity were assayed in the extract. The average total phenolic compound result indicated that momordica charantia was significantly higher in antioxidant content (P<0.05) and the effect of momordica charantia extract was highly significant in HEPG2 cells than HCT116 as well as MCF-7 which showing the IC50 of Momordica charantia extract in HEPG2 was 0.80 ug/ml while in HCT116 was 0.87 ug/ml and was 1.50 ug/ml in MCF-7 cell respectively. Also the effect of the Momordica charantia extract was more potent in HCT116 compared to MCF-7 cells.
Keywords: Phenolic compounds, DPPH, Apoptosis, MCF-7, HepG2, HCT116.
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