European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF PROTECTIVE EFFECT OF PHYLLANTHUS AMARUS SEEDS ON PARACETAMOL INDUCED HEPATOTOXICITY AND NEPHROPROTECTIVE IN RATS

Syed Asad B.*, Md. Majid Iqbal and Rohit Saraswat

ABSTRACT

To assess the hepatoprotective and nephroprotective effect of Phyllanthus amarus seeds extract on Paracetamol induced Hepatotoxicity and Nephrotoxicity. The antioxidant status of liver and kidneys were improved by substantiate protection of cellular damage induced by highly reactive toxic intermediates formed during biotransformation of paracetamol. In the present study test extract shown presence of polyphenolic compound and demonstrated antioxidant activity. The 70% methanolic extract 250 mg/kg of Phyllanthus amarus seeds have shown promising results as compared to aqueous extract of 300 mg/kg. Therefore the study concludes that the 70% methanolic extract of Phyllanthus amarus seeds have antioxidant and organ protective property. The results obtained in this study indicate that Phyllanthus amarus seeds possess hepatoprotective and nephroprotective activity. Methanolic extract effects were comparable to silymarin and cystone, and were highly significant, whereas aqueous extract were less potent compared standard drugs. Due to strong capability by reducing the enhanced levels of liver and kidney function blood parameters. Histopathological observation exhibited the improved hepatic and renal anatomy that is reversed the damage almost equal to standard drugs. Thus 70% metonolic extract of Phyllanthus amarus seeds possess a potent hepatoprotective and nephroprotective activity.

Keywords: Hepatoprotective, Nephroprotective, Paracetamol, Phyllanthus amarus.