Abstract
EVALUATION OF PROTECTIVE EFFECT OF PHYLLANTHUS AMARUS SEEDS ON PARACETAMOL INDUCED HEPATOTOXICITY AND NEPHROPROTECTIVE IN RATS

Syed Asad B.*, Md. Majid Iqbal and Rohit Saraswat

ABSTRACT

To assess the hepatoprotective and nephroprotective effect of Phyllanthus amarus seeds extract on Paracetamol induced Hepatotoxicity and Nephrotoxicity. The antioxidant status of liver and kidneys were improved by substantiate protection of cellular damage induced by highly reactive toxic intermediates formed during biotransformation of paracetamol. In the present study test extract shown presence of polyphenolic compound and demonstrated antioxidant activity. The 70% methanolic extract 250 mg/kg of Phyllanthus amarus seeds have shown promising results as compared to aqueous extract of 300 mg/kg. Therefore the study concludes that the 70% methanolic extract of Phyllanthus amarus seeds have antioxidant and organ protective property. The results obtained in this study indicate that Phyllanthus amarus seeds possess hepatoprotective and nephroprotective activity. Methanolic extract effects were comparable to silymarin and cystone, and were highly significant, whereas aqueous extract were less potent compared standard drugs. Due to strong capability by reducing the enhanced levels of liver and kidney function blood parameters. Histopathological observation exhibited the improved hepatic and renal anatomy that is reversed the damage almost equal to standard drugs. Thus 70% metonolic extract of Phyllanthus amarus seeds possess a potent hepatoprotective and nephroprotective activity.

Keywords: Hepatoprotective, Nephroprotective, Paracetamol, Phyllanthus amarus.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW OCTOBER ISSUE PUBLISHED

    OCTOBER 2020 Issue has been successfully launched on 1 October 2020.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT