Nilesh Patel, Dr. Janmejay Patel, Achal Patel, Payal Patel, Dr. Ankitkumar M. Paneliya*


Introduction: Despite the availability of advanced medicinal systems, approximately 80% of the world population still depends on herbs and herbal formulations for the treatment of arthritic conditions. Though it is in use for wide variety of clinical applications, toxicological evaluation of herbal ingredients or combinations is still in infancy. Aim: To evaluate acute oral toxicity on Swiss albino mice and efficacy with anti-oxidant properties on arthritic rats of Amvatri capsule. Method: The protocol of present study was certified by IAEC (SKPCPER/IAEC/2016-02/05) as per the CPCSEA. The acute oral toxicity was assessed according to OECD guideline AOT-425 to know single dose (2000 mg/kg) toxicity of test drug on swiss albino mice. Animals were periodically observed individually for 14 days for any clinical signs of toxicity or mortality after administration of test drug. Bovine serum denaturation assay (In-vitro) was done to investigate effectiveness of Amvatri capsule on arthritis. FCA induced arthritis animal model (In-vivo) was adopted to check therapeutic effectiveness of Amvatri capsule against arthritis. FCA was challenged to sub plantar region after treatment in Rats and various parameter were measured i.e. paw volume, arthritic index, hematological and radiological parameters. Different assay analysis (total protein, SOD activity, Catalase activity, Lipid peroxidation) were done to establish its anti-oxidant properties. Results: There were no physical changes, behavioral changes and mortality observed in Swiss albino mice during 14 days. Body weight of all animals did not reveal any significant change as compared to vehicle control group. Amvatri capsule decreased significantly paw volume, Arthritic index, hematological parameters compared to disease control group. The significant increase in SOD and calalase level was found in test drug treated group. Conclusion: The No-Observed-Adverse-Effect-Level (NOAEL) of Amvatri capsule is 2000 mg/kg. The results suggest anti- inflammatory, anti-arthritic and antioxidant effect of Amvatri capsule.

Keywords: Poly herbal formulation, Amavatari capsule, NOAEL, Mortality, OECD Guideline, Rheumatoid Arthritis, Anti-oxidant.

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