Abstract
SPECTROPHOTOMETRIC ESTIMATION OF PROMETHAZINE HYDROCHLORIDE IN PHARMACEUTICAL PREPARATIONS

Nief Rahman Ahmed*, Amenah Ibrahim Ahmed and Nadia Cheni Saadallah

ABSTRACT

A simple, accurate, and rapid visible spectrophotometric method has been developed for the determination of Promethazine Hydrochloride in pure form, pharmaceutical preparations and environmental water samples. The method is based on the oxidation of Promethazine hydrochloride by sodium hypochlorite in a Sulfuric acid medium to form a pinkish red colored product with an absorption maximum at 518 nm. Beer’s Law was obeyed in the range of 2-28 μg/ml with molar absorptivity of 0.978×104 L.mol.-1.cm-1. The relative standard deviation of the method was less than 2% and accuracy (average recovery) was 100±0.98%. The optimum conditions for all color development are described and the proposed method has been successfully applied for the determination of Promethazine Hydrochloride in pharmaceutical preparations and water samples. The common excipients and additives did not interfere in the proposed method.

Keywords: Promethazine Hydrochloride, Sodium hypochlorite, spectrophotometric.


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