European Journal of Biomedical and Pharmaceutical Sciences

A REVIEW ON SELF EMULSIFYING DRUG DELIVERY SYSTEM

Sunitha Reddy M.* and Pallavi Dongre

ABSTRACT

The oral route is the most preferred route for the drug administration. But the major problem in oral drug formulations is low bioavailability which leads to poor water solubility. Some approaches are being studied for the improvement of solubility and bioavailability of poorly aqueous soluble drugs such as BCS class II and class IV drugs. One of the novel approache is Self-emulsifying drug delivery system. SEDDS are isotropic mixtures of oil, surfactant, solvents, and cosolvents/surfactants. These forms fine emulsion in the GI-tract upon mild agitation produced by gastric mobility. Present review describes about composition, Mechanism of self-emulsification, Advantages and Disadvantages, and evaluation of Self emulsifying drug delivery system.

Keywords: Self emulsifying drug delivery system, SMEDDS, SNEDDS, Isotropic mixture, Pseudo ternary phase diagrams.