Sandrine Donfack Mewoabi*, Nguedia Jules Clement Assob and Theresa Akenji Nkuo


Background: Hepatitis B and HIV have similar mode of transmission. The presence of one can negatively influence the outcomes of the other. There is not enough data to show the magnitude of Hepatitis B burden in HIV infected people in Cameroon. This study seeks to estimate the prevalence of Hepatitis B and associated factors among people living with HIV on antiretroviral therapy (ART), attending four care and treatment centers for routine follow up across three regions of Cameroon. Materials and Methods: This was a multicenter hospital-based cross-sectional study conducted from June 2016 to April 2017 among people living with HIV on antiretroviral treatment in Major care and treatment centers across three regions of Cameroon (Bamenda, Buea and Douala). Information on socio-demographic variables, and medical history was captured using a structured questionnaire. Hepatitis B surface antigen (HBsAg) denoting Hepatitis B infection was measured using an Immunochromatographic tests. Descriptive statistics were used to summarize the data and the strength of association was determined using the logistic regression model. Results: Participants who consented to the study were 952 people living with HIV on antiretroviral treatment. Of whom, 76.8% were females. Eighty- three (8.7%), were screened positive for HBsAg (95% CI: 7.1–10.7%), indicating hepatitis B infection. The highest HBV/HIV co-infection prevalence was observed in participants from the Littoral Region (9.4%), followed by the south west (8.3%) and Northwest (7.5%). Male participants were 4 times more likely to be HBsAg positive than females. Coinfection was higher in participants in the age range less than 31years (11.9%) and those with low CD4+T lymphocytes counts (11.3% and 12.0% for counts less than 200 and 200-350 respectively). Coinfection stood at 16.3% in People who were less than 1year on antiretroviral treatment. Males with a history of tattooing were 3 times more likely than others to be HBsAg positive, although there was no significant association in the bivariate logistic model (OR; 3.90, 95% CI: 0.97-15.66, p=0.053 and OR; 2.86, 95% CI: 0.83-9.87, p=0.097) respectively). No significant association was observed in the multivariate logistic model. Conclusion: HIV/HBV co-infection is frequent in our setting. We recommend the routine screening of PLWH for HBsAg and other HBV markers in order to limit poor treatment outcomes due to coinfection.

Keywords: HBsAg Co-infection, HIV, HBV, Prevalence, Cameroon.

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