Abstract
FORMULATION AND CHARACTERIZATION OF FLOATING MATRIX TABLETS OF TIZANIDINE HYDROCHLORIDE

*Bhambar Kunal V. and Dr. Pande Shrikant D.

ABSTRACT

Tizanidine Hydrochloride used in the control of spasticity, which is indicated in muscle pain as muscle relaxant. Tizanide Hydrochloride is crystalline powder. Tizanidine hydrochloride stimulates adrenergic receptors in the central nervous system, inhibiting presynaptic release of norepineprine and increasing the inhibitory effect on alpha motor neurons and motor reflexes. In the present investigation, efforts were given to develop a sustained release floating matrix tablets of Tizanidine Hydrochloride. Gastro retentative drug delivery system improve the pharmacotherapy of the stomach itself through local drug release leading to high drug concentrations at the gastric mucosa, which sustained over a long period of time. Floating matrix tablets were prepared by direct compression method using sodium bicarbonate and citric acid as gas forming agents. HPMC K100M and Ethyl cellulose were used in the formula to retard drug release. Floating matrix tablets were evaluated for different quality attributes. In vitro drug release showed that polymer percentage is enough to extend the release of the drug for at least 12 hr. The dissolution curve shows that formulation TF-6 shows maximum drug release 89.57 % at the end of 12 hours while TF- shows least 68.22%.

Keywords: Ethyl Cellulose, Floating Matrix Tablets, HPMC K100M, Tizanidine Hydrochloride.


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