European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS, CHARACTERIZATION AND ANTI BACTERIAL ACTIVITY OF 4-(1-HYDROXY-2-METHYLPROPAN-2-YLIMINO)METHYL)-2,6-DIMETHXYPHENOL

J. Sreeramulu, Nadipineni Nagaraju*, P. Malleswarareddy G. Ramamohan and M. Rafiyuddin

ABSTRACT

A new organic Schiff base compound [4-((1-Hydroxy-2-Methyl Propan-2-Ylimino) Methyl)-2,6, Dimethxy Phenol] was synthesized by condensation of 2-amino-2-methyl-1-propanol with 4-hydroxy-2.6- di methoxy benzaldehyde and characterised by elemental analysis, electronic, Infra-red spectra, polarography and coulometry. The electrochemical studies of Schiff base in presence of cadmium as reference standard were carried out in Briton-Robinson buffer solutions of pH 2.1 – 10.1. Effect of Mercury column height was carried out at pH 4.10. Kinetic parameters of redox behavior were carried out at pH 2.10-10.10. Millicoulometric analysis was carried out to know the number of electrons involved in the redox behavior of different functional groups from this study the author has calculated an important parameter K0f,h ( in cm sec-1) at PH 2.1 4.1 6.1 8.1 10.1 as 5.18x10-4, 2.76x10-4 , 9.97x10-5 10.4x10-5 ,10.4x10-5 respectively. Further the free energy change at different PH values was calculated. The details of results are well presented in the present research investigation. The test Schiff base 4-((1-hydroxy-2-methylpropan-2-ylimino)methyl)-2,6-dimethxyphenol shows significant antibacterial activity against pathogenic bacterial strains (Bacillus cereus, Escherichia coli, Klebsiella pneumonia, Salmonella typhi, Staphylococcus aureus) causes infectious diseases in humans.

Keywords: 2-Amino-2-Methyl-1-Propanol, antibacterial activity, Kinetic parameters and coulometry.