European Journal of Biomedical and Pharmaceutical Sciences

UNDERSTANDING AVARANA IN RELATION WITH INSULIN RESISTANCE W.S.R TO MADHUMEHA

Dr. Vijayalakshmi S.*, Dr. Abdul Khader and Dr. Kiran M. Goud

ABSTRACT

Madhumeha is a disease known to mankind since time immemorial. It is a type of Vataja Pramaeha, among the twenty varieties of Prameha explained in our classics. Madhumeha is characterised by mutra and tanu madhuryata and similar clinical features are observed in Diabetes mellitus. Two types of pathologies can occur in Madhumeha. In first type Vata prakopa is due to Dhatu kshaya which is said to be asadhya and second type where Madhumeha occurs due to Avarana to gati of Vata by vriddhi of Kapha, Pitta, mamsa or medas individually or in combination.  This pathology can be understood with respect to Insulin resistance seen in type 2 Diabetes mellitus, which can be corelated with various conditions like Inflammatory changes, Glucose toxicity, amyloid deposition and Lipid toxicity in relation with Insulin resistance. Analysing the avaraka will help in proper understanding of samprapti which further help in planning up the accurate treatment. Hence an attempt is made in this paper to understand avarana in relation to Insulin resistance caused by Kapha dosha as the Glucose toxicity, Pitta dosha in the form of Cytokines synthesis causing inflammation, Mamsa avarana causing amyloid deposition and medo avarana by lipid toxicity.

Keywords: Prameha, Madhumeha, Avarana, Type 2 Diabetes mellitus, Glucose toxicity, Lipid toxicity, Insulin resistance.