Abstract
A REVIW ON INTRANASAL ROUTE DRUG DELIVERY SYSTEM

Raj Nandani Pal*, Arpita Singh, Amresh Gupta, Shivangi Palival and Nitish Kumar

ABSTRACT

Intranasal distribution is non-invasive essentially painless does not require sterile preparation and is facilely and yarely administered by the patient or a medico in an emergency setting. The utilization of the nasal route for the distribution of challenging drugs such as diminutive polar molecules vaccines hormones peptides and proteins has engendered much interest in nowadays. Due to the high permeability high vasculature and low enzymatic environment of nasal cavity and avoidance of hepatic first pass metabolism are well felicitous for systemic distribution of drug molecule via nasal discerner. Additionally the applications of nasal route for distribution of peptides and proteins, non-peptide drugs, vaccines and drug molecules to CNS have been summarized in depth. This review sets out to discuss some intra Nasal Route Distribution systems, Barriers to drug convey from nasal perceiver to encephalon, dosage forms, preparation and evaluation, application.

Keywords: Intra Nasal Route Delivery systems, Barriers to drug transport from nose to brain, dosage forms, preparation and evaluation.


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