European Journal of Biomedical and Pharmaceutical Sciences

MATRIX TABLET: AN APPROACH TOWARDS EXTENDED RELEASE OF DRUG DELIVERY

Pallavi Chand*, Pratibha, G. Gnanarajan and Preeti Kothiyal

ABSTRACT

For many past decade oral route administration is most frequent used process as per it is most conventional process for patient and economically cheaper as compare to other administrational process. Matrix tablet offer an important tool for oral extended- release dosage form. Hence matrix system are favoured because of its simplicity, patient compliances etc. The problems like drug targeting, local side effect, frequency administration and fluctuation in blood concentration level can be solved. Oral extended release drug delivery system become very important approach for those drugs which are having slow half life and high dose frequency. Matrix tablet are mainly formulated either by wet or direct compression method using polymers like Poly Methyl Methacrylate (PMMA), Polyglycolic acid, HPMC and many more. The Matrix may be use for hydrophilic, hydrophobic, mineral or biodegradable types. Most of the drugs, if not formulated properly, may readily release the drug at a faster rate, and are likely to produce toxic concentration of the drug on oral administration.

Keywords: matrix tablet, extended release, polymers.