Abstract
FORMULATION DEVELOPMENT AND CHARACTERIZATION OF CURCUMIN LOADED SOLID LIPID NANOPARTICLES

*K. Kumar and Amreen

ABSTRACT

Curcumin is a yellow hydrophobic polyphenol derived from the rhizome of turmeric that is safe and beneficial in several ailments. Low aqueous solubility and poor bioavailability were important of disadvantages of curcumin. The aim of the present study was to formulate the curcumin solid lipid nanoparticles (SLNs) with increased bioavailability profile and improved pharmacological activity. The SLNs were prepared by a hot homogenization coupled with ultrasonication method using tripalmitin, tween 80 and poly vinyl alcohol. The optimized blank SLNs formulations were utilized to entrap curcumin and characterized for particle size, polydispersity index, zeta potential, shape, drug encapsulation efficiency, and in vitro drug release. The prepared SLNs were analyzed by FT-IR spectroscopy to confirm the cross-linking reaction between drug, lipid and surfactants. The results demonstrated that the particle size, polydispersivity index, zeta potential, encapsulation efficiency and loading capacity of the SLNs were 214.60± 3.55nm, 0.49±0.03, -29.63±0.50mV, 51.99±4.14% and 5.33±0.34%, respectively. AFM images showed spherical to circular particles with well defined periphery. In vitro drug release exhibited biphasic pattern with an initial burst release of 16.5% within 2h followed by sustained release over 96h. FT-IR study suggested that during the process of formulations, lipid and surfactants have not reacted with the drug to give rise to reactant products and it was only physical mixture.

Keywords: Curcumin, Solid Lipid Nanoparticles, Hot homogenization in vitro release.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • EJBPS: APRIL ISSUE PUBLISHED

    APRIL 2021 Issue has been successfully launched on 1 April 2021.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT