Abstract
A COMPARATIVE STUDY OF SYNBIOTIC AND PREBIOTIC SUPPLEMENTATION ON GUT HEALTH, SCFA, HS-CRP AND LIPID PROFILE OF TYPE 2 DIABETIC SUBJECTS WITH PRE HYPERTENSION.

Mini Sheth*, Mojibur Rohman Khan, Madhusmita Dehingia, Abnita Thakuria, Vasundhra Chand

ABSTRACT

Objective: The study was designed to determine the impact of synbiotic and prebiotic supplementation on gut health, hs-CRP, lipid profile and short chain fatty acids (SCFA) of type 2 diabetic subjects with pre hypertension. Methods: 60 pre hypertensive with type 2 NIDDM subjects were selected purposively from Sun Valley Hospital, Assam, India. The subjects were randomly divided into Control (N=10), Synbiotic group (N=25) and Prebiotic group (N=25) based on their informed consent. The synbiotic group was supplemented with 1 gm of freeze dried synbiotic product and the prebiotic group with 10 ml of fructo oligosaccharide (FOS) daily to be taken along with meals, for 45 days. All the parameters were determined using standard methods. Results: Synbiotic supplementation showed a significant improvement in the gut health of the subjects by increase in LAB and Bifidobacteria by 32.6% and 131.6% respectively and prebiotic supplementation resulted in a significant increase in LAB and Bifidobacteria by 77.6% and 29.7 % respectively. Synbiotic supplementation and prebiotic resulted in a significant reduction on hs-CRP and in TG, TC, LDL, VLDL and a significant increase in HDL and prebiotic supplementation showed a significant reduction in the TG, TC, LDL, VLDL and a significant increase in HDL. Synbiotic and prebiotic resulted in an increase in fecal butyrate levels and fecal propionate levels. Conclusion: Daily intake of 1 g synbiotic product and 10 ml FOS improves gut health, hs-CRP, lipid profile and short chain fatty acids (SCFA) of the subjects which may be due to increased production of SCFA.

Keywords: Diabetes, SCFA, synbiotic, prebiotic.


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