Abstract
DOCKING OF SHORT CHAIN PEPTIDES TEMPORINS WITH EBOLA VIRUS TARGET 4IBK

P. Selvamani*, S. Latha, M. Arputha Bibiana, G. Vinothkumar, M. Sathish kumar

ABSTRACT

The needs of unexplored molecules in the treatment of emerging highly dangerous viral infections are increasing day by day. The discovery of new compounds or molecules will be of highly expensive and so we aim to screen the reported short chain peptides with antibacterial property whose susceptibility against viral pathogens are unknown. Temporins are nine different types of small peptides with a maximum of 13 aminoacids. They are chosen as ligands and the viral protein VP 35 with PDB Id 4IBK was chosen as target. The docking was performed for these 9 different combinations in ZDOCK software of Discovery Studio version 3.1 (30 days trial) and the ZScore of all the docked structures were noted. The viral target showed promising scoring of -120.50 with AP00110 4IBK and -112.45 with AP00108 4IBK.

Keywords: Tamporins family, 4IBK, protein-peptide interactions, ZDOCK.


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