Francesco Perticone, Gian Luigi de’Angelis, Loreto Gesualdo, Alessandra Graziottin, Alessandra Mangia* and Stefano Vicari


The antipyretic and analgesic properties featuring paracetamol allow this drug to dominate the medical scenes since the late 19th century. Nowadays, while moving toward a patient-centered healthcare system, an increasing interest is dedicated to paracetamol administration in vulnerable subpopulations including children, pregnant women, and older people with comorbidities. The aim of this paper is to review the applications of a widely consumed drug worldwide and its appropriate use during lifespan by setting aside some common misconceptions and contrasting the spread of fake news. A customized multidisciplinary board including pediatrician, child and adolescent neuropsychiatrist, gynecologist, hepatologist, nephrologist, gastroenterologist, internal and geriatric physician was set up. By applying the most recent evidence in literature to corroborate the clinical suggestions, this review offers precise answers to specific hot clinical questions.

Keywords: Paracetamol, acetaminophen, pain, pregnancy, elderly.

[Full Text Article]


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