CONSUMPTION OF RIDA BITTERS ATTENUATES HYPERGLYCEMIA, INSULIN RESISTANCE AND OXIDATIVE STRESS, AND SUPPRESS INFLAMMATION IN A RAT MODEL OF TYPE 2 DIABETES
Ajao Folasade Omobolanle*, Abiola Samad, Oyadeyi Ayodele Stephen, Adeyinka Nurudeen Opeyemi, Kalejaye Noheem Olaolu
ABSTRACT
Background: Diabetes mellitus has been identified as a chronic syndrome that has become wide-ranging and yet without type distinction is a leading cause of manifold complications. The disease is associated with glucose metabolism resulting from defects in insulin secretion and action. Aim: This study aimed to explore the effect of RIDA herbal bitters on diabetic insulin-resistant rat model. Materials and Methods: 32 Adult male rats of Wistar strain, weighing 160g ±20g were randomized into 4 groups of n=8. Diabetes was induced by High-fat fed diet and 25 mg/kg b.wintraperitoneal Streptozotocin. Treated animals were administered 200 mg/kg p.o of the reference drug and 0.3ml p.o RIDA bitters orally. Samples were collected by cardiac puncture after 28 days of administration. Results: There was an increase in body weight (p<0.05), hyperglycemia (p<0.05), insulin resistance and HOMA-IR (p<0.05) in high-fat fed and STZ induced diabetic group when compared with control. IL-6, TNF-α, Adiponectin and Insulin concentration were significantly reduced in RIDA/Metformin treated groups.The administration of RIDA bitters significantly decrease (p<0.05) total cholesterol, low density lipoprotein, triglyceride, SOD, CAT, GPx, Urea, Uric acid, Creatinine and significantly increase (p<0.05)High Density Lipoprotein-Cholesterol and MDA activities in the RIDA/ Metformin treated groups compared to STZ group. In addition, GGT, Aspartate aminotrasferase, Alkaline Phosphatase and Alanine Transaminase activities were significantly reduced (p<0.05) in the RIDA group compared to STZ. Conclusion: The results provide evidence that RIDA is a possible beneficial product for type II diabetes and its associated metabolic disorders.
Keywords: Diabetes mellitus, RIDA bitters, Streptozotocin, High-fat diet, Inflammation, oxidative stress.
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