Abstract
EFFECT OF HEXANE AND ETHANOL EXTRACTS OF ACALYPHA WILKESIANA ON LIPID PROFILE AND OXIDATIVE STRESS MARKERS

Joy O. Oyebisi*, Osaro Iyekowa, Amowie P. Oviawe and Sylvanus O. Innih

ABSTRACT

Background: Acalypha wilkesiana Hoffmanni commonly has been reported to possess many beneficial phytoconstituents. The effect of hexane and ethanol extracts of Acalypha wilkesiana Hoffmannii on lipid profile and oxidative stress markers were investigated. Methods: A total of 60 rats were divided into 12 groups with 5 rats in each group; Group A received 5mls/kg of distilled water /day, group B received 5% of tween 80, group C received 20mg of margarine dissolved in 100ml of vegetable oil and group D received low dose (75mg/kg) of the Hexane extract only. Rats from group E received high dose (150mg/kg) of the Hexane extract only, group F received low dose (75mg/kg) of the Ethanol extract only, group G received high dose (150mg/kg) of the Ethanol extract only, group H received 20mg of margarine dissolved in 100ml of vegetable oil for one month after which they were treated with atorvastatin10mg/kg while group I received 20mg of margarine dissolved in 100ml of vegetable oil for one month after which they were treated with low dose (75mg/kg) of the hexane extract, group J received 20mg of margarine dissolved in 100ml of vegetable oil for one month after which they were treated with high dose (150mg/kg) of the hexane extract. Other rats from group K received 20mg of margarine dissolved in 100ml of vegetable oil for one month after which they were treated with low dose (75mg/kg) of the ethanol extract while group L (received 20mg of margarine dissolved in 100ml of vegetable oil for one month after which they were treated with high dose (150mg/kg) of the ethanol extract. Administration and weighing were done for the period of 60days after which the rats were sacrificed under chloroform anesthesia and the heart and blood tissue were harvested for Lipid profile and Oxidative stress analysis. Results: Group C (Hypercholesterolemic rats) gave a total cholesterol value of 179.30±0.83 and Low Density Lipoprotein (LDL) value of 56.11±0.87, group H (Hypercholesterolemic rats treated with atorvastatin10mg/kg) gave a total cholesterol value of 151.3±11.18 and Low Density Lipoprotein (LDL) value of 31.93±3.10, group I (Hypercholesterolemic rats treated with the low dose of the hexane extract) gave a total cholesterol value of 147.22±15.43 and LDL value of 39.45±5.99, group J (Hypercholesterolemic rats treated with the high dose of the hexane extract) gave a total cholesterol value of 150.13±4.81 and LDL value of 35.68±2.59, group K (Hypercholesterolemic rats treated with the low dose of the ethanol extract) gave a total cholesterol value of 171.91±9.08 and LDL value of 54.77±5.77 while group L (Hypercholesterolemic rats treated with the high dose of the ethanol extract) gave a total cholesterol value of 150.15±13.21 and LDL value of 48.43±3.03. Conclusion: Both the low and high doses of the hexane extracts of Acalypha wilkesiana significantly reduced both the Total Cholesterol level and the low density lipoprotein (LDL) (P-value <0.05) when compared with the Hypercholesterolemic rats. There was a significant increase in the antioxidants parameters (Gluthathione Peroxide (GPx), Superoxide Dismutase (SOD), Catalase (CAT)) and a reduction in Malondialdehyde (MDA) when compared with the Hypercholesterolemic rats (P-value<0.05).

Keywords: Hypercholesterolemia, Acalypha wilkesiana, Lipid Profile, Oxidative Stress, Antihypercholesterolemic activites, Green Acalypha.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tanima Debnath Sarkar

Download Article : Click here

News & Updation

  • EJBPS: NOVEMBER ISSUE PUBLISHED

    NOVEMBER 2021 Issue has been successfully launched on 1 November 2021

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT