European Journal of Biomedical and Pharmaceutical Sciences

A STUDY ON THE PREVALENCE OF HOSPITAL ACQUIRED MDR INFECTION IN A TERTIARY CARE HOSPITAL

Parvathy K. J.*, Asna Hassan  and Vivek P.

ABSTRACT

The Pathogenic species resistant to antibiotics is one of the most urgent and difficult challenge to the public health. Due to the inappropriate usage of antibiotics, new microbial resistance mechanisms, procedures under aseptic conditions are results in failure of microbial response to standard treatment leading to increased morbidity, expenditures for healthcare and an immense risk of death. Now days the multidrug resistant infections are more common in hospitals. The study was conducted to evaluate the prevalence of hospital acquired MDR infections and the various MDR pathogens found in MICU patients. The prevalence of hospital acquired MDR infection in 100 patients was found to be 26%. Among culture positive patients a total of 100 bacterial isolates 7% had mixed bacterial growth. Which the most common species were MDR Gram-negative isolates. MDR Klebsiella pneumonia 40%, followed by Methicillin resistant S. aureus 28% and AcinetobacterBaumani 11%, MRS Haemolyticus 11%, MDR E.coli 10%, MDR pseudomonas aeruginosa were found to be 4%. From the 26% of hospital acquired MDR infections, they were commonly due to catheter induced 11% , ventilator associated 8% , 4% were central line associated , 2% due to surgical site infections, 1% was due to the usage of higher end antibiotics . Selection of appropriate antibiotics, optimizing dosing and de-escalation based on antibimicrobial sensitivity. Appropriate sterilization of medical devices and educating patients on wound care practices are essential to reduce the burden of this infection and associated healthcare costs.

Keywords: Multidrug resistance, morbidity, Hospital acquired MDR, catheter, ventilator, surgical site infection.