Dr. Jano N. Zore, MD, Dr. Ian Antao Pereira, MD, Dr. J. P. Tiwari, MD DM FISN and Dr. Shubham M. Naik*


Normal physiology of an individual is governed by varied factors ranging from age, sex, race, diet and physiological and biochemical functioning of the organ systems. The authors herein would like to highlight and stress upon in detail about the kidneys. The kidneys are important organ in our body which has many functions apart from regulation of the electrolytes and the fluid content of the body as well as the regulation of blood pressure. We wish to discuss the patient’s kidney function in context of different disorders and drugs that can affect the tests as well as alter normal kidney function (nephrotoxic). Any alteration in functioning of the kidneys can result in alteration of metabolism and excretion of the drugs, thus resulting in increased levels of the drugs in the blood and increased risk of adverse drug effects, which may be either symptomatic or asymptomatic. An important and reliable indicator of kidney function amongst the parameters are serum creatinine level, decrease in kidney function reflecting as increased serum creatinine.

Keywords: Creatinine, eGFR, factors modifying.

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