Abstract
ETHOSOMES: NOVEL VESICULAR CARRIERS FOR ENHANCED TRANSDERMAL DELIVERY OF HERBAL DRUGS

Sudha S., Noosila M. K.*, Anusha P. and Vivek M. C.

ABSTRACT

Phytomedicines are used worldwide by human being from ancient times. Herbal drugs are becoming more popular in the modern world for their application to cure variety of diseases with less toxic effects and better therapeutic effects. However these medicines suffer less penetration into skin. To minimize this problem novel drug delivery systems (Ethosomes) are used nowadays. Novel drug delivery system is valuable in delivering the bioactive at controlled rate and delivery of bioactive at the target that reduces the adverse effects with the increase in bioavailability of the bioactive. Ethosomes are lipid based elastic vesicles containing phospholipids, alcohol (ethanol and isopropyl alcohol) in relatively high concentration and water. High concentration of ethanol enhances the topical drug delivery and prolongs the physical stability of Ethosomes with respect to liposomes. It has been shown that the physicochemical characteristics of Ethosomes allow this vesicular carrier to transport active substances more efficaciously through the stratum corneum into the deeper layers of the skin than conventional liposomes. Ethosomes entrap drug molecule with various physicochemical characteristics i.e. of hydrophilic, lipophilic, or amphiphilic. Ethosomes possess many advantages when compared with transdermal or dermal drug delivery system. Large molecules like proteins, peptide molecule is possible, increased skin permeation, non-toxic, in comparison to oral drug delivery system as it eliminates gastrointestinal interference & first pass metabolism of drug.

Keywords: Ethosomes, herbal drugs, vesicular carrier, ethanol.


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