Abstract
PREVALENCE OF THROMBOCYTOPENIA, PLATELET TRANSFUSION AND HEPATIC INVOLVEMENT IN DENGUE FEVER, IN A TERTIARY CARE HOSPITAL

Aneetta Tom Mattom*, Akash Babu, Cijo George

ABSTRACT

Dengue is one among the foremost common vector- borne malady in Southeast Asia & has been stratified into the most vital mosquito- borne viral disease with epidemic potential in the world. Globally the incidence of this infectious disease has increased in recent years. This is an observational cohort study conducted over a period of 6 months in the general medicine department of a tertiary care hospital in Kerala. Case records were retrospectively reviewed for demographic data, clinical presentations, investigations, management, and outcome. Data analysis was conducted using SPSS and Microsoft Excel 2010. The study was conducted to evaluate the prevalence of thrombocytopenia, platelet transfusion and hepatic involvement in dengue fever. This study was done to assess the patterns of hepatic involvement, thrombocytopenia in patient with dengue fever & time taken for clinical/ biochemical recovery. A total of 173 patients were selected for our study based on inclusion and exclusion criteria. The prevalence of thrombocytopenia was found to be 48% in our study. The majority of patients in our study recovered within 4 days. 7.5% of the study subjects undergone platelet transfusion and out of that 4.6% of the transfusion were done at 11,000- 20,000 level of platelet count. Hepatic involvement & recovery time were analysed and it was observed that majority of patients recovered within 4 days and there was a significant association between recovery time and transaminase level (P<0.001). As the transaminase level increases time to recovery also increases. The odds for developing thrombocytopenia in patients with hepatic involvement in our study were found to be 5.78 times greater than those without hepatic involvement.

Keywords: Dengue; Nadir count; Platelet count; SGOT; SGPT; Thrombocytopenia.


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