Abstract
HEPATOPROTECTIVE ACTIVITY OF SEENTHIL CHOORANAM

S. Ushakanthan*

ABSTRACT

Siddha medicine is one of the most ancient medical systems of South Asian region of the world. Seenthil chooranam is one of the Siddha medicinal drug with huge medicinal properties. The drug Seenthil chooranam mentioned in classical siddha text Agasthiyar paripuranam – 400 for its hepato-protective activity. Liver is a vital organ which participates in biotransformation, detoxification of substances and excretion of toxins and chemicals. But there are some instances where the liver hepatocytes undergo hepatotoxicity. Hepato protective effects are attributed to the efficient antioxidant activity of the Seenthil Chooranam, which restores the peroxidases activity in the liver. Therefore, Seenthil Choornam by regulating these substances carry out hepato-protective activity. In this research work activity of Seenthil choornam on SGPT, SGOT and SALP, Total bilirubin and Total protein on CCl4 induced liver damage in rats. Healthy and either sex of five groups of wistar albino rats of (150- 200g) body weight were used for this study purpose. Group I received 10 ml/kg body weight of ghee orally once daily for 9 days. Groups III-IV rats were pre-treated with the extract of Seenthil Choornam 200 and 400 mg/kg for 7 days once daily by gastric intubation. Groups II - V rats were administered 1.25 ml/kg of CCl4. Group V were fed with standard drug Silymarin 25mg/kg. In this study blood samples revealed increased levels of serum enzymes SGOT, SGPT and SALP were detected in mouse treated with CCl4. And administration of S.Chooranam decreased the hepatocyte damage same like the standard drug given.

Keywords: Hepato-protective, Seenthil chooranam, liver, Enzymes.


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