Abstract
PRECLINICAL EVALUATION OF ANTIUROLITHIATIC ACTIVITY OF CITRUS SINENSIS LEAVES

Nilesh Desai*, Dr. Kishorkumar Burade and Dr. Ritesh Agrawal

ABSTRACT

Urolithiasis is the most common disorder of the urinary tract. The worldwide incidence of urolithiasis is quite high and in spite of tremendous advances in the field of medicine, there is no truly satisfactory drug for treatment of renal calculi. The common use of Citrus Sinensis in treating kidney stone and other disorders in urinary tract deserves special attention from pharmacologist. Nevertheless, it is hard to find studies which explain the antiurolithiatic property of Citrus Sinensis. It has traditional claim for the diuretic and kidney disorder. It has not been scientifically well documented for use in urolithiasis. Hence the present study was undertaken to explore antiurolithiatic properties of Citrus Sinensis. In the present study antiurolithiatic activity of aqueous extract of Citrus Sinensis (AECS) leaves was tested against ethylene glycol induced urolithiasis in rats. AECS showed significant changes in different parameters such as urine volume, urine pH, electrolyte contents of urine, nitrogenous substances in urine, serum nitrogenous substances, kidney wt. etc.

Keywords: Urolithiasis, Citrus Sinensis, Renal Calculi, Diuretic, AECS.


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