European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND IN-VITRO EVALUATION OF VOGLIBOSE DISPERSIBLE TABLETS

Abhishek Raj*

ABSTRACT

The primary objective of this study was to prepare dispersible tablets of Voglibose in two different strengths of 0.2 and 0.3 mg respectively. Voglibose is an oral hypoglycemic drug used effectively in the treatment of type-2 diabetes mellitus. These tablets were prepared by direct compression method using Croscarmellose sodium as a super disintegrant and Orange DC 100 PH was used as a flavouring agent in these tablets. The prepared tablets were evaluated for various physicochemical parameters such as flow properties, hardness, weight variation, thickness, friability, disintegration time, in vitro dissolution studies, assay and uniformity of content. These tablets were also subjected for real time and accelerated stability studies as per ICH guidelines. These tablets were found to be stable even after 6 months of stability study as all the parameters were within limit as per the specifications of Indian Pharmacopoeia.

Keywords: Voglibose, dispersible tablets, direct compression, hypoglycemic, diabetes.