European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF THE ANTIOXIDANT ACTIVITY OF FIRST (G1) AND SECOND GENERATION (G2) PPI DENDRIMERS FUNCTIONALIZED WITH 4-HYDROXYCOUMARIN

Talibouya Ndior*, Fatou Dieng Faye, El Hadji Gorgui Diouf, Mouhamadou Fofana, Lahat Niang, Nicolas Cyrille Ayessou, Ibrahima BA and Moussoukoye Diop

ABSTRACT

The work presented focuses on the synthesis and characterization of first- and second-generation dendrimers (G1) & (G2) functionalized with 4-hydroxycoumarin of antioxidant utilities. Today, it is demonstrated with irrefutable evidence that free radicals are the main culprits of aging and degenerative diseases such as cancer, cardiovascular disease, cataracts, immune system decline and brain dysfunction. This is why it is more than important to isolate and ∕or synthesize new molecules in order to effectively fight against these diseases. The study and evaluation of synthetic antioxidants has become a popular and reliable object of research as it aims to develop and discover powerful new antioxidant molecules without risk to the body. The study of antioxidant activity carried out by the DPPH• method revealed that the synthesized dendrimers exhibit antioxidant activity. All the results obtained have been encouraging. The C2 compound, with a percentage of 56.87% catches our attention.

Keywords: Dendrimers, 4-Hydroxycoumarin, Antioxidant, DPPH, PPI.