FORMULATION AND EVALUATION OF SMEDDS CONTAINING EZETIMIBE BY EMPLOYING ARACHIS OIL AS OIL AND TWEEN 80, PEG 400 AS SURFACTANT SYSTEM
P. Tripura Sundari* and P. Mounika
ABSTRACT
Solubility is the important process for most of the drug to solubilize in a given solvent to give homogenous solution. The greater the solubility of drug, the greater will be the systemic dissolution showing desired pharmacological response. New techniques have been developed to improve the solubility rate of poorly soluble drugs. Solid dispersion, Complexation, Particle size reduction, co-solvency, etc. Among which, a recent approach lipid base formulations (SMEDDS) are attracting the formulation scientists. These lipid based formulations include SMEDDS, SNEDDS. SMEDDS are nothing but the emulsion containing oil, surfactant, co-surfactant and drug which form oil in water emulsion upon mild agitation with aqueous phase. In the present study SMEDDS containing Ezetimibe, a BCS class II drug is formulated. As Ezetimibe is insoluble in water, lipid based formulations SMEDDS are developed by employing arachis oil as lipid phase, Tween 80, PEG400 were selected as surfactant mixture. The better formulations were selected based on the evaluation parameters like drug content, %transmittance, drug release studies.
Keywords: SMEDDS (self micro emulsifying drug delivery system), Ezetimibe, PEG 400, Tween 80, Ternary diagram.
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