Abstract
DEVELOPMENT OF CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF FAVIPIRAVIR FROM BULK DRUG AND TABLET DOSAGE FORM

*Anamika Damodare and Rajashri D. Ingale

ABSTRACT

The aim of study is to develop and validate a new, simple, rapid, precise, and accurate An Eco-friendly RP-HPLC and UV-Method Development and Validation for an estimation of Favipiravir in Bulk and pharmaceutical dosage form. To perform all the validation parameters according to ICH guidelines. To Optimize the validated parameters. FAV belongs to class II in the Biopharmaceutics Classification System (BCS). High permeability and low water solubility. To develop and validate a new, simple, rapid, precise, and accurate An Eco-friendly RP-HPLC and UV-Method Development and Validation for an estimation of Favipiravir in Bulk and pharmaceutical dosage form. To perform all the validation parameters according to ICH guidelines. To Optimize the validated parameters. Method development was done by using column (Cosmosil) C18 column (250 mm X 4.6 mm i.d.) 5μm, mobile phase Methanol: 0.2% Glacial acetic acid (pH 3.00) (20:80 % v/v), flow rate 0.5 ml/min, sample size 20 ml, run time 5 min. Validation parameters like accuracy, precision, repeatabilitystudies, specificity, solubility, LOD, LOQ and stability testing was performed on Favipiravir. From the calibration curve it was concluded that the Favipiravir shows linear response in the range of 2.0-30.0 μg /ml. All the parameters were within range hence above method is validated.

Keywords: Favipiravir, HPLC, Accuracy, stability, specificity, linearity, filtration etc.


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