FORMULATION AND EVALUATION OF MELPHALAN LOADED NIOSOME FOR CANCER TREATMENT
Dr. H. Padmalatha*, K. Srujana, M. Aarthi, Saba Anjun, Busheera, J. Anusha, T. Prabhakar Rao and CH. Rajalakshmi
ABSTRACT
Niosomes presents a structure similar to liposomes and hence they can they can represent alternative vesicular system with representative to liposomes. Niosomes thought to be better candidate for drug delivery as compared with liposome due to various factor like cost, stability and etc. Entrapment efficiency for different niosomal formulations were calculated and it was found that the F1 formulation had the highest entrapment of 97.12 % and the lowest entrapment of 88.06 % was found from formulation F3. The Zeta potential of the formulation F2 had the highest value of -14.4 and the formulation F1 had lowest value of -0.29. No charge inducing agents were added to these formulations and thus the potential value is low. In-vitro drug release data was studied by using dialysis method for all the prepared niosomal formulations and from this study, it was found that formulation F1 had the maximum percentage release of 96.10 % at the end of the 24th hour. The drug release kinetics for all the prepared niosomal formulations were studied by computational modelling method from this study it was found that F1 formulation followed Hixon with R2 values 0.9877, F2 formulation followed Higuchi with R2 values 0.9553 and F3 formulation followed First order with R2 values 0.9723 respectively.
Keywords: Formulation, Evaluation, Melphalan, Niosome, Cancer Treatment.
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