Abstract
FORMULATION AND EVALUATION OF MELPHALAN LOADED NIOSOME FOR CANCER TREATMENT

Dr. H. Padmalatha*, K. Srujana, M. Aarthi, Saba Anjun, Busheera, J. Anusha, T. Prabhakar Rao and CH. Rajalakshmi

ABSTRACT

Niosomes presents a structure similar to liposomes and hence they can they can represent alternative vesicular system with representative to liposomes. Niosomes thought to be better candidate for drug delivery as compared with liposome due to various factor like cost, stability and etc. Entrapment efficiency for different niosomal formulations were calculated and it was found that the F1 formulation had the highest entrapment of 97.12 % and the lowest entrapment of 88.06 % was found from formulation F3. The Zeta potential of the formulation F2 had the highest value of -14.4 and the formulation F1 had lowest value of -0.29. No charge inducing agents were added to these formulations and thus the potential value is low. In-vitro drug release data was studied by using dialysis method for all the prepared niosomal formulations and from this study, it was found that formulation F1 had the maximum percentage release of 96.10 % at the end of the 24th hour. The drug release kinetics for all the prepared niosomal formulations were studied by computational modelling method from this study it was found that F1 formulation followed Hixon with R2 values 0.9877, F2 formulation followed Higuchi with R2 values 0.9553 and F3 formulation followed First order with R2 values 0.9723 respectively.

Keywords: Formulation, Evaluation, Melphalan, Niosome, Cancer Treatment.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: JUNE ISSUE PUBLISHED

    JUNE 2024 Issue has been successfully launched on 1 JUNE 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT