Abstract
OCUSERTS AS SMART OCULAR DRUG DELIVERY SYSTEMS - AN OVERVIEW

Pasam Jyothirmayi*, A. Anusha, V. Pravallika, T. Priyanka, T. Prasanthi, P. Sireesha and T. Manasa

ABSTRACT

Ocuserts are sterile ocular preparations that may follow a controlled release technique to extend medication residence duration and reduce nasolacrimal discharge. The goal of the ocuserts is to improve retention time with conjunctiva tissue to provide consistent drug release. Uniform ocular medication levels decrease systemic side effects, minimizes dose, boosting patient compliance. The significance of ocuserts, their polymers, preparation methods were elaborated in this review. By overcoming the ocular barriers they provide extended corneal contact duration is the major success in ocular medication delivery. Non-conventional approaches like liposome, microsphere, prodrug, etc. may improve ocular drug delivery systems and reduce side effects. Diffusion, osmosis, or bioerosion are the various methods that govern drug release from ocusert. Ocuserts have wide applications in both local as well as systemic affects of drug.

 

Keywords: Ocuserts, Minidiscs, Glaucoma, Bioerosion, Diffusion.


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