Abstract
BACTERIOLOGICAL PROFILE OF BRONCHOALVEOLAR LAVAGE AND THEIR ANTIBIOGRAM BY VITEK-2 IN TERTIARY CARE HOSPITAL, BANGLADESH

Dr. Abu Naser Ibne Sattar* and Dr. Sanjida Khondakar Setu

ABSTRACT

Background: Bronchoalveolar lavage (BAL) is a medical diagnostic procedure in which a bronchoscope is passed through the mouth or nose into an appropriate airway in the lung with a measured amount of fluid introduced and then collected for examination. BAL may have an important role in reaching a specific diagnosis, characterizing alveolitis, and monitoring patients during treatment and follow-up. Methods: To examine the bacterial etiology of BAL fluids among tertiary care patients in Bangladesh with pulmonary infections, a cross-sectional study was conducted over a period of one year from January to December 2022. A total of 245 BAL fluid samples were examined and antimicrobial susceptibility of isolates were carried out by VITEK® 2 automated culture system. Result: Out of the 245 samples, 161 samples were culture positive. Among 6 different isolates (4 Gram-negative and 2 Gram-positive), Pseudomonas aeruginosa (49.06 %) was predominant followed by Klebsiella pneumoniae (26.70 %). A higher infection rate was seen among males (55.90 %) and in the age group 51-60 years (30.0 %). Colistin was the most effective drug against all the gram-negative bacteria followed by amikacin, imipenem and netilmicin. High degree of resistance was seen against cephalosporins and ciprofloxacin. Among gram positive isolates the most effective drugs were vancomycin (100%) and linezolid (100%). Staphylococcus aureus isolates were 100% Methicillin sensitive (MSSA). Conclusions: Bronchoalveolar lavage has improved diagnostic efficacy of pulmonary infections. It facilitates the early detection of pulmonary diseases diagnosis and which helps to have an updated local antibiogram for each hospital. Thus, detection of bacterial agents from BAL fluid can be a basis for successful antimicrobial therapy for patients with pulmonary infections.

Keywords: Bacteriological profile, BAL, MDR, Antimicrobial sensitivity, Respiratory infection.


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