Abstract
GENETIC STUDY OF THE METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISMS IN IRAQI COLORECTAL PATIENTS

Thooalnoon Younes Aljanabi*

ABSTRACT

Forty blood samples of CRC patients were collected, besides blood samples were taken from twenty apparently healthy persons and considered as control groups. Polymerase chain reaction restriction fragment length polymorphism (RFLP-PCR) technique was used to detect MTHFR C677T and A1298C polymorphisms, ELISA kit for homocysteine measurement was used. Genotype analysis of MTHFR A12987C revealed AA: 42.5%, AC: 30% and CC 27.5% among CRC cases and 25%, 40% and 35% among controls, while MTHFR C677T undetectable. Homocysteine measurement revealed significant increase (p<0.05) with CRC risk, 21.351±1.84 nmol/ml among patients and 6.97± 9.16 nmol/ml among controls. In conclusion homocysteine increase significantly among CRC patients. MTHFR 1298 A/C and C/C genotypes have no effect on CRC Iraqi patients, and this probably due to ethnic diversity in this study.

Keywords: Genetic polymorphism - colorectal cancer - methylenetetrahydrofolate - genomic DNA, Iraq.


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