European Journal of Biomedical and Pharmaceutical Sciences

OPIOID INDUCED RHABOMYOLYIS PRESENTING WITH MYOPATHY

Dr. Amitabh Saha*, Dr. Amit Kumar, Dr. SK Saini, Dr. RC Das, Dr. K Chatterjee

ABSTRACT

Opioid is a psychoactive substance with high habit forming property. Opioid dependence and at times over dosing may cause acute muscle damage with elevated serum aspartate aminotransferase and creatine kinase activities, increased serum myoglobin concentrations, raised plasma creatinine concentrations, hypocalcaemia and hyperphosphataemia. These abnormalities may worsen if not treated and gets complicated due to the development of acute renal failure (requiring haemodialysis). Clinical evidence of myopathy is minimally reported but is known to occur in very few cases. The case described below presented to psychiatric OPD with muscle weakness and features of opioid poisoning.

Keywords: Opioid, dependence, rhabdomyolysis, acute renal failure, hemodialysis, withdrawal.