Abstract
FORMULATION AND EVALUATION OF DESVENLAFAXINE SUCCINATE MICROCAPSULES

N. Santhi Priya*, P. Siva Krishna, P. Srinivasa Babu, D. Amani, K. Sree Pujitha, K. Tejasri,
Ch. Vinay Babu and T. Seshu Reddy

ABSTRACT

Desvenlafaxine succinate (DSV) is a water soluble anti-depressant drug, which is rapidly absorbed after oral administration exaggerating its side effects. The current work is aimed to prepare controllable release DSV matrix to reduce DSV side effects related to its initial burst. Sustained release microcapsules of Desvenlafaxine Succinate were prepared by ionotropic gelation method. Microcapsule system is one of the novel drug delivery system found applications in many areas of science and technology. This microcapsules to overcome the drug-related adverse effects like gastric irritation, improve its bioavailability. Total ten formulation batches (F1-F10) were formulated using sodium alginate aloneand combination with sod.CMC, Carbopol 934, Guargum and HPMC K100 polymers as drug release modifiers in various properties and investigated for physicochemical properties and drug release potential. All investigated properties showed satisfactory results. Increase in the concentration of polymers dispersions increased size distribution, flow properties and mean diameter of the microcapsules. The drug entrapment efficiency obtained in the range 70% to 94.03%. In-vitro study drug release in batch F9and F10 showed faster release than F5, F6,F7 and F8. The mechanism of drug release from Microcapsules was found to be following Case-II transport. From the study it was concluded that controlled release Desvenlafaxine Succinate Microcapsules can be developed successfully by using ionotropic gelation technique.

Keywords: Desvenlafaxine Succinate, Microcapsules, Ionotropic gelation technique, Sustained release, Sodium alginate.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: APRIL ISSUE PUBLISHED

    APRIL 2024 Issue has been successfully launched on 1 APRIL 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT