European Journal of Biomedical and Pharmaceutical Sciences

THE IMPACT OF IMMEDIATE PREOPERATIVE THROMBOTIC CHEMOPROPHYLAXIS FOR BARIATRIC SURGERY, RETROSPECTIVE STUDY AT KING HUSSEIN MEDICAL CENTER

Ramadan Hassanat*, Yousif ALsardi, Quatiba Qatwena, Rashid ALshahwan and Huda ALkhreisat

ABSTRACT

Background: Obesity is a global public health concern with substantial impacts on morbidity, mortality, and the
economy. Bariatric surgery has emerged as an effective solution for addressing obesity-related challenges.
However, patients undergoing such surgeries face an increased risk of venous thromboembolism event. Tinzaparin
sodium (Innohep), has shown efficacy in the management of VTE. We intend to study the effect of preoperative
Innohep in bariatric surgery. Methods: This retrospective, single-center, comparative study, conducted at King
Hussien Medical Hospital in Jordan, aimed to assess the impact of immediate pre-operative administration of
Tinzaparin sodium on postoperative outcomes in bariatric surgery. Data from 230 patients were analyzed, with 110
not receiving pre-operative chemoprophylaxis (Group A) and 120 receiving 4500 IU Innohep at induction (Group
B). Demographic, clinical, and operative variables were collected, and statistical analyses were performed using R
software. Results: Patients in the study had a mean age of 35.0, and the majority were female (77%). Group B,
receiving Tinzaparin, showed a significant difference in the type of bariatric surgery, with fewer Laparoscopic
Sleeve Gastrectomy (LSG) procedures. Post-operative complications were significantly higher in Group B,
particularly bleeding (9.2%). The study emphasized BMI and postoperative WBC levels as potential risk factors
for postoperative bleeding. Conclusion: The study recommends cautious consideration of BMI and postoperative
WBC levels in preoperative assessments to mitigate the risk of bleeding. Tinzaparin sodium's role in preventing
postoperative bleeding requires further investigation, addressing study limitations, and incorporating long-term
follow-up to enhance patient outcomes in bariatric surgery.

Keywords: preoperative; anti-thrombotic; bariatric surgery; obesity.