CARDIOPROTECTIVE EFFECT OF LUFFA ACUTANGULA LEAF EXTRACT AGAINST DOXORUBICIN INDUCED MYOCARDIAL DAMAGE IN WISTAR RATS
*Ch. Lochana, M. Ganesh Kumar, Dr. K. Atchuta Kumar and K. Sirisha
ABSTRACT
The present study was chosen for the leaf of Luffa acutangula for the scientific evaluation of cardioprotective
potential based on the presence of bioactive compounds which is used to prevent cardiotoxicity. Acute oral
toxicity study was carried out for evaluating the safety and toxic effect of ethanolic extract of Luffa acutangula
leaf. From this study the result showed the ethanolic extract of Luffa acutangula leaves extract does not have any
toxic effect upto the dose of 2000mg/kg body weight. The In vivo study was conducted with 4 groups of wistar
rats, 6 animals in each group. For assessing the cardioprotective activity, Doxorubicin induced cardiotoxicity
model was used. The doses of plant extract was chosen for the test to be 200 and 400mg/kg body weight of the
animal. The antioxidant enzyme (SOD, CAT, GPx) level was decreased in Dox induced cardiotoxic rats heart
homogenate which is compared with normal control group. The pretreatment of EELA leaf to Dox administered
animals showed significantly increased antioxidants level in heart homogenate. Dox induced cardiotoxic group
increased lipid peroxidation parameter like MDA level and it was significantly decreased in EELA treated group.
Histopathological studies in isolated heart revealed that the pretreatment of EELA leaf prevent the myocardial
damage and restored the normal architecture of the heart. From this study, it is concluded that the ethanolic extract
of Luffa acutangula was found to possess the cardioprotective activity. Further findings to explore the possible
mechanism of action of isolated compound from this plant against cardiotoxicity.
Keywords: Cardioprotective Effect, Luffa Acutangula, Leaf Extract, Doxorubicin, Wistar Rats.
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