European Journal of Biomedical and Pharmaceutical Sciences

ANTIPSYCHOTIC PROPERTY OF GREWIA HIRUSTA VAHL ETHANOLIC LEAF EXTRACT IN ALBINO MICE

J. Vinay*, A. Srivani

ABSTRACT

The antipsychotic qualities of Grewia hirusta Vahl leaves were examined in this study. Grewia hirusta Vahl is a
plant that is known to have ethno medical importance and is a member of the Malvaceae family. The leaves were
gathered, shade-dried, and ground into a powder.70% ethanol was used for the extraction process, and stirring was
done occasionally (Maceration).This study looked into the extract's initial Phytochemical screening. Antipsychotic
efficacy was assessed using the Tail Suspension method and haloperidol-induced catalepsy. The Phytochemical
such as phenols, flavonoids, glycosides, phenolics, saponins, and tannins make up the majority of the extract. The
outcome demonstrated a substantial reduction in cataleptic time and a dose-dependent effect in mice using the Tail
Suspension technique. In mice, Grewia hirusta Vahl's ethanol extract had strong antipsychotic effects. To examine
the plant drug's mechanism of action regarding anti-dopaminergic function and to establish it as an antipsychotic
medication, more neurochemical research and in vitro investigations are required.

Keywords: Grewia hirusta Vahl, antipsychotic, Catalepsy, Haloperidol, Imipramine.