European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF ANTI-UROLITHIATIC ACTIVITY OF ETHANOLIC EXTRACT OF WHOLE PLANT OF OCIMUM BASILICUM AGAINST ETHYLENE GLYCOL INDUCED UROLITHIASIS

S. Dada Khalandar*, Dr. Shainaz Begum and Dr. P. Dharani

ABSTRACT

The Urolithiatic activity may induced by chemical induced model: Ethylene glycol (EG) (0.75% v/v), and
ammonium chloride(1% w/v) may leads to hyperoxaluria in male wister rats. Several parameters were used
including urinary volume, urine pH, serum calcium, uric acid, urea and creatinine to assess lithiatic activity. Oral
administration of OBEE 200 and 400mg/kg could significantly inhibited Ca oxalate crystal disposition in renal
tubules and protected against changes in polyurea and kidney weight loss. Stone forming promoters like oxalate,
calcium, phosphate, uric acid and urea were increased in disease control group compare to normal control group
rats. Deposition of crystalline components like calcium, phosphate and uric acid were increased in renal tissue
compare to normal control group rats. Treatment with OBEE SOD, CAT levels were increased compare to disease
control group.

Keywords: Ocimum basilicum, Urolithiasis, Ethylene glycol, Ammonium chloride, Antiurolithiatic, Ethanolic extracts.