European Journal of Biomedical and Pharmaceutical Sciences

CHARACTERIZATION AND PERFORMANCE EVALUATION OF HICEL HFS IN DIRECT COMPRESSION TABLET FORMULATION

Rauf Pathan*, Monika Tomar and Amit Raj Sinha

ABSTRACT

Direct Compression is the shortest method to manufacture tablets and co-processed excipient is the best choice for
direct compression tablet formulation due to its outstanding physical properties. HiCelTM HFS is manufactured
using the co-processed method and contains Mannitol, colloidal silicon dioxide, and a binder. A preferred binder is
Microcrystalline cellulose. The composition has improved compressibility, particle size, lubrication sensitivity,
and ejection force during tableting and gives higher tablet hardness at low compression force compared to
individual excipient dry mix or either alone in the preparation of solid dosage form Tablet formulation. Tablets
comprising the co-processed composition, an active, and optionally or more other excipient. This co-processed
excipient composition was also suitable for Pharmaceutical, herbal, and nutraceutical tablets, it helps to protect
API from moisture, and it will help to improve the flow of herbal extract flow and reduce die-frication during
tableting. In this study, we will discuss the superiority of HiCelTM HFS like characterization, evaluation, and
tableting.

Keywords: Moisture Sensitive, Compressibility, Direct Compression, Scanning Electron Microscope (SEM), FTIR.