HEARING RECOVERY USING TWO MODALITIES: PREDNISONE VERSUS PREDNISONE WITH ACYCLOVIR IN TREATMENT OF PATIENTS WITH IDIOPATHIC SUDDEN SENSORINEURAL HEARING LOSS
Shatha Abutineh Ph*, Dr. Khaled Al Sarayreh, Dr. Amin Daoud, Dr. Ala’a Al Salaheen and Dr. Muayyad Al Shakhnbeh
ABSTRACT
Objective: To investigate whether combining an antiviral drug to systemic steroids assists retrieval in the medical
management of idiopathic sudden sensorineural hearing loss. Patients and Methods: The study was conducted on
42 individuals who had presented to our clinic with proved diagnosis. of idiopathic sudden sensorineural hearing
loss. The involved individuals were selected randomly to one of the following two categories: Group I:
Prednisolone (of a maximum dose of 80 mg/day for a period of four days, then lowered over 10 days) was given to
21 patients in addition to a placebo. Group II: Patients who given prednisone in combination with acyclovir (one
gram, every eight hours for 10 days) (21 patients). The variations in the level of hearing in the afflicted ear (from
start to final) was calculated as the Average Pure Tone (PTA), This was determined by taking the average of the
thresholds at 0.5, 1, 2, and 4 KHz. Secondary outcome assessments were speech discrimination scores (SDS).
Results: There were no differences that were statistically significant (p > 0.05) in the level of change in PTA and
SDS between the initial presentation and the last assessment between the two groups. Conclusion: In individuals
with Sudden Sensorineural Hearing Loss, Steroid treatment enhances recovery outcomes considerably.In the
treatment of idiopathic sudden sensorineural hearing loss, antiviral therapy did not outperform steroid alone.
Keywords: Idiopathic sudden sensorineural hearing loss, prednisone, Acyclovir.
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