REVIEW ON THERAPEUTIC POTENTIAL OF SNAKE VENOM AS ANTICANCER THERAPY
Nandhini A., Nekketha S., Snehadevi M. and B. Premkumar*
ABSTRACT
One of the main causes of death in the globe is cancer. It is crucial to find new medications made from natural ingredients. The fundamental problem with the way cancer is now treated is that after initial treatments, the disease develops a resistance to medication. As a result, the use of anticancer drugs made from natural sources has increased. The diversity of snake venom is a unique reservoir from which new medicines can be developed. There is a lot of potential for some of the components in snake venom to be used as anticancer drugs. Snake venom contains the toxin, which is a mixture of compounds predominately composed of proteins and peptides. The activation of cytotoxicity, apoptosis, cell cycle arrest, and prevention of metastasis, angiogenesis, and tumour growth are just a few of the anti-tumour properties of snake venom toxins. Here, we discuss the role of crude snake venom and toxins, such as phospholipids A2, L-amino acid oxidase, C-type lectin, and this integrin, as possible anticancer medicines that have been studied in cancer cell lines and animal tumour models and compared to normal cell lines.
Keywords: Cancer, Snake venom, Anti-tumour drug, Carcinogenesis.
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