Abstract
IN–VITRO BIOEQUIVALENCE ASSESSMENT OF FOUR DIFFERENT BRANDS OF LOOP DIURETICS- TORSEMIDE TABLETS

Aravanan P.*, Jeevanandham S., Ragavi M., Shanmugapriya C., Mohamed Musthafa, Mohammed Salih M. and Rithikadevi T.

ABSTRACT

The objective of the current study was to the four distinct Torsemide brands that are sold commercially in the local
pharmacy by physiochemical evaluation and UV analysis. Four different brands of Torsemide tablets were
compared for their physicochemical equivalency using official standards outlined as per the Indian
Pharmacopoeia. These parameters included uniformity in weight, friability, hardness, disintegration, dissolution
rate, and drug content. The four evaluated brands were all bioequivalent and met the requirements of the official
tests for friability, weight uniformity, disintegration, and dissolution. The results of the friability test fell within the
given range. In less than 30 minutes, every formulation begins to crumble. Based on their dissolution examination,
the tested brands were formulated a per the required standard. These four different brand tablets had percentage
contents of the active component that met the monograph's requirements. From a biological and chemical
standpoint, all four of the examined brands may be deemed similar. The rate and absorption of drug that enters the
biological system in an active state and can have the desired pharmacological effect, As per the results, patients
can change brands the desired brands without risk.

Keywords: Torsemide, bioavailability, bioequivalence, comparison study, physicochemical evaluation.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: APRIL ISSUE PUBLISHED

    APRIL 2024 Issue has been successfully launched on 1 APRIL 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT